Cardiolipin Antibody (IgA) details
What Cardiolipin Antibody (IgA) shows
Anti-cardiolipin antibodies are autoantibodies that mistakenly target cardiolipin, a phospholipid found in cell membranes and involved in normal blood clotting regulation. This IgA subtype is one of three antibody classes (along with IgG and IgM) tested as part of the antiphospholipid antibody panel, used to help diagnose antiphospholipid syndrome — an autoimmune condition that raises the risk of blood clots, recurrent miscarriage, and other pregnancy complications. IgA anti-cardiolipin antibodies are less commonly included in standard diagnostic criteria than IgG and IgM, but can still be clinically relevant, especially when other antiphospholipid markers are positive. A single positive result is usually confirmed with repeat testing at least 12 weeks later, since transient positives can occur with infections or other conditions.
Tests that include Cardiolipin Antibody (IgA)
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjogren's syndrome.
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
This test measures anticardiolipin IgG, IgA, and IgM antibodies to evaluate suspected cases of antiphospholipid syndrome (APS).
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgG) An antibody that attacks the body's own phospholipids (IgG type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgM) An antibody that attacks the body's own phospholipids (IgM type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
The antiphospholipid antibody syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g. arterial or venous thrombosis, pregnancy morbidity) and persistent positive antiphospholipid antibodies (IgM, IgG Cardiolipin or b2GPI antibodies greater than the 99th percentile; or a lupus anticoagulant). International consensus guidelines for APS suggest waiting at least 12 weeks before retesting to confirm antibody persistence. The Systemic Lupus International Collaborating Clinics immunological classification criteria for systemic lupus erythematosus (SLE) include testing for isotype IgA, which has yet to be incorporated into APS criteria. Low level antiphospholipid antibodies may sometimes be detected in the setting of infection, drug therapy or aging.
- Beta-2-Glycoprotein I Antibody (IgA) Measures IgA antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgG) Measures IgG antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgM) Measures IgM antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgG) An antibody that attacks the body's own phospholipids (IgG type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgM) An antibody that attacks the body's own phospholipids (IgM type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Phosphatidylserine/ Prothrombin Antibody (IgG) Measures IgG antibodies against the phosphatidylserine/prothrombin complex, used alongside other antiphospholipid tests when looking at clotting or pregnancy-loss risk.
- Phosphatidylserine/ Prothrombin Antibody (IgM) Measures IgM antibodies against the phosphatidylserine/prothrombin complex, used alongside other antiphospholipid tests when looking at clotting or pregnancy-loss risk.
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly systemic lupus erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis, and primary Sjögren's syndrome.
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgG) An antibody that attacks the body's own phospholipids (IgG type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgM) An antibody that attacks the body's own phospholipids (IgM type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
The Thrombotic Risk Assessment assesses an individual's risk for developing a thrombotic event, such as a stroke or heart attack, by measuring factors affecting blood clotting.
- Homocysteine An amino acid byproduct of protein metabolism. Elevated levels are linked to increased cardiovascular risk and can reflect low B vitamin (B12, folate, B6) status.
- Protein C Activity Measures the activity of Protein C, a natural anticoagulant. Low activity is linked to an increased risk of blood clots.
- Activated Protein C Resistance Checks whether your blood resists the natural anticlotting action of activated protein C, most often caused by the inherited factor V Leiden variant.
- Antithrombin III Activity Measures the activity of a protein that naturally helps prevent excessive blood clotting. Low levels are linked to an increased risk of blood clots.
- Beta-2-Glycoprotein I Antibody (IgA) Measures IgA antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgG) Measures IgG antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgM) Measures IgM antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgG) An antibody that attacks the body's own phospholipids (IgG type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgM) An antibody that attacks the body's own phospholipids (IgM type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Dilute Russell's Viper Venom Time (DRVVT) Screen A clotting test that helps screen for lupus anticoagulant, an antibody linked with a higher risk of blood clots and some pregnancy complications.
- Factor II (F2) DNA Analysis A genetic test for the prothrombin (Factor II) G20210A variant, an inherited change in the F2 gene that can raise the tendency to form blood clots.
- Lupus Anticoagulant Detects lupus anticoagulant, an antiphospholipid antibody that prolongs clotting tests in the lab but is linked to an increased risk of blood clots.
- Plasminogen Measures the activity of plasminogen, the protein that becomes plasmin to break down blood clots, used when assessing clotting and bleeding risk.
- Protein S Antigen, Free The unbound, biologically active portion of Protein S, a natural anticoagulant. Low levels raise the risk of blood clots.
- PTT-LA Screen A clotting-time screen sensitive to lupus anticoagulant, an antibody linked to blood clots, used as a first step in antiphospholipid testing.
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