Activated Protein C Resistance details
What Activated Protein C Resistance shows
Activated protein C is one of your body's natural brakes on clotting, working by breaking down clotting factors V and VIII. This test checks how well your plasma responds to it. It is measured when looking for causes of blood clots in the veins, especially at a young age, in unusual places or when clots run in the family. Resistance to activated protein C suggests an increased tendency to clot, and it is most often caused by an inherited change in factor V known as factor V Leiden. Some blood thinners, pregnancy and other clotting problems can affect the result, so an abnormal result is usually confirmed with a genetic test for factor V Leiden.
Tests that include Activated Protein C Resistance
Activated protein C (APC) resistance is the most frequent hereditary defect associated with deep vein thrombosis. Over 95% of the APC resistance phenotype is due to the Factor V Leiden mutation. The APC-Resistance assay is a plasma-based functional test for the determination of APC resistance caused by the factor V Leiden mutation.
- Activated Protein C Resistance Checks whether your blood resists the natural anticlotting action of activated protein C, most often caused by the inherited factor V Leiden variant.
The Thrombotic Risk Assessment assesses an individual's risk for developing a thrombotic event, such as a stroke or heart attack, by measuring factors affecting blood clotting.
- Homocysteine An amino acid byproduct of protein metabolism. Elevated levels are linked to increased cardiovascular risk and can reflect low B vitamin (B12, folate, B6) status.
- Protein C Activity Measures the activity of Protein C, a natural anticoagulant. Low activity is linked to an increased risk of blood clots.
- Activated Protein C Resistance Checks whether your blood resists the natural anticlotting action of activated protein C, most often caused by the inherited factor V Leiden variant.
- Antithrombin III Activity Measures the activity of a protein that naturally helps prevent excessive blood clotting. Low levels are linked to an increased risk of blood clots.
- Beta-2-Glycoprotein I Antibody (IgA) Measures IgA antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgG) Measures IgG antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgM) Measures IgM antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgG) An antibody that attacks the body's own phospholipids (IgG type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgM) An antibody that attacks the body's own phospholipids (IgM type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Dilute Russell's Viper Venom Time (DRVVT) Screen A clotting test that helps screen for lupus anticoagulant, an antibody linked with a higher risk of blood clots and some pregnancy complications.
- Factor II (F2) DNA Analysis A genetic test for the prothrombin (Factor II) G20210A variant, an inherited change in the F2 gene that can raise the tendency to form blood clots.
- Lupus Anticoagulant Detects lupus anticoagulant, an antiphospholipid antibody that prolongs clotting tests in the lab but is linked to an increased risk of blood clots.
- Plasminogen Measures the activity of plasminogen, the protein that becomes plasmin to break down blood clots, used when assessing clotting and bleeding risk.
- Protein S Antigen, Free The unbound, biologically active portion of Protein S, a natural anticoagulant. Low levels raise the risk of blood clots.
- PTT-LA Screen A clotting-time screen sensitive to lupus anticoagulant, an antibody linked to blood clots, used as a first step in antiphospholipid testing.
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