Phosphatidylserine/ Prothrombin Antibody (IgM) details
What Phosphatidylserine/ Prothrombin Antibody (IgM) shows
Phosphatidylserine/prothrombin (aPS/PT) antibodies are autoantibodies that target a complex formed by prothrombin, a clotting protein, and phosphatidylserine, a fat found on cell membranes. This test measures the IgM type in your plasma. It is used as part of an antiphospholipid antibody evaluation in people with unexplained blood clots or recurrent pregnancy loss. A positive result is associated with lupus anticoagulant and antiphospholipid syndrome, though IgM results can sometimes be transient, for example after an infection. Because aPS/PT is not a formal classification criterion, it is interpreted alongside other antiphospholipid tests, and positive results are usually repeated weeks later.
Tests that include Phosphatidylserine/ Prothrombin Antibody (IgM)
The antiphospholipid antibody syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g. arterial or venous thrombosis, pregnancy morbidity) and persistent positive antiphospholipid antibodies (IgM, IgG Cardiolipin or b2GPI antibodies greater than the 99th percentile; or a lupus anticoagulant). International consensus guidelines for APS suggest waiting at least 12 weeks before retesting to confirm antibody persistence. The Systemic Lupus International Collaborating Clinics immunological classification criteria for systemic lupus erythematosus (SLE) include testing for isotype IgA, which has yet to be incorporated into APS criteria. Low level antiphospholipid antibodies may sometimes be detected in the setting of infection, drug therapy or aging.
- Beta-2-Glycoprotein I Antibody (IgA) Measures IgA antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgG) Measures IgG antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Beta-2-Glycoprotein I Antibody (IgM) Measures IgM antibodies against beta-2-glycoprotein I, one of the antiphospholipid antibodies, used to evaluate antiphospholipid syndrome and causes of blood clots.
- Cardiolipin Antibody (IgA) An antibody that attacks the body's own phospholipids (IgA type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgG) An antibody that attacks the body's own phospholipids (IgG type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Cardiolipin Antibody (IgM) An antibody that attacks the body's own phospholipids (IgM type). One of the markers used to help diagnose antiphospholipid syndrome, which raises the risk of blood clots and pregnancy complications.
- Phosphatidylserine/ Prothrombin Antibody (IgG) Measures IgG antibodies against the phosphatidylserine/prothrombin complex, used alongside other antiphospholipid tests when looking at clotting or pregnancy-loss risk.
- Phosphatidylserine/ Prothrombin Antibody (IgM) Measures IgM antibodies against the phosphatidylserine/prothrombin complex, used alongside other antiphospholipid tests when looking at clotting or pregnancy-loss risk.
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