Scleroderma (Scl-70) Antibody details
What Scleroderma (Scl-70) Antibody shows
Scl-70 (also called anti-topoisomerase I) antibodies are autoantibodies strongly associated with diffuse systemic sclerosis (scleroderma), the more widespread and generally more severe form of the disease, which — unlike the limited form associated with centromere antibodies — can more significantly affect internal organs, including the lungs and heart, in addition to the skin. A positive result, particularly combined with suggestive symptoms like Raynaud's phenomenon and widespread skin thickening, supports this diagnosis and often prompts closer monitoring for lung and heart involvement.
Tests that include Scleroderma (Scl-70) Antibody
Scl-70 Antibodies are autoantibodies directed against topoisomerase I. They are primarily associated with systemic sclerosis (scleroderma), particularly the diffuse cutaneous form, and can help support diagnosis and assess disease severity.
- Scleroderma (Scl-70) Antibody An autoantibody strongly associated with diffuse systemic sclerosis (scleroderma), a more widespread form of the disease.
Scl-70 Antibodies are autoantibodies directed against topoisomerase I. They are primarily associated with systemic sclerosis (scleroderma), particularly the diffuse cutaneous form, and can help support diagnosis and assess disease severity.
- Scleroderma (Scl-70) Antibody An autoantibody strongly associated with diffuse systemic sclerosis (scleroderma), a more widespread form of the disease.
ANA + 11 Components is a comprehensive blood test that includes the presence of antinuclear antibodies (ANAs), which are autoantibodies targeting the cell nucleus. A positive ANA screen suggests potential autoimmune activity. 11 ANA Components tests for 11 specific autoantibodies against distinct nuclear antigens, helping to identify or differentiate particular autoimmune diseases.
- Chromatin Antibodies Autoantibodies that target chromatin (DNA-protein complexes) inside your cells. Associated with lupus and other autoimmune conditions.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
- Ribosomal P Antibody An autoantibody associated with lupus, particularly linked to neuropsychiatric symptoms in some patients.
- RNP Antibody An autoantibody associated with mixed connective tissue disease and, at times, lupus.
- Smith (Sm) Antibody An autoantibody highly specific for lupus, though present in only a portion of people with the disease.
- Centromere B Antibody Autoantibodies that target a structure inside your cells called the centromere. Strongly associated with limited scleroderma (CREST syndrome).
- Double-Stranded DNA (dsDNA) Antibody Antibodies against double-stranded DNA. Highly specific for lupus and often used to track disease activity.
- Scleroderma (Scl-70) Antibody An autoantibody strongly associated with diffuse systemic sclerosis (scleroderma), a more widespread form of the disease.
- Sjögren's Syndrome A (SS-A/Ro) Antibody An autoantibody associated with Sjögren's syndrome and lupus; also relevant in pregnancy due to a risk of neonatal heart complications.
- Sjögren's Syndrome B (SS-B/La) Antibody An autoantibody associated with Sjögren's syndrome and lupus, often found alongside SS-A antibodies.
- Sm/RNP Antibody Measures antibodies to the Sm/RNP complex, autoantibodies linked to mixed connective tissue disease and lupus, used when evaluating a positive ANA.
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