Anti-Jo-1 details
What Anti-Jo-1 shows
Anti-Jo-1 is an autoantibody that targets an enzyme involved in protein synthesis, and it's the most common of a group of antibodies called anti-synthetase antibodies. Its presence is strongly associated with antisynthetase syndrome, an autoimmune condition that typically involves some combination of muscle inflammation (myositis, including polymyositis and dermatomyositis), interstitial lung disease, joint inflammation, and characteristic skin changes on the hands ('mechanic's hands'). Testing for anti-Jo-1 is typically prompted by symptoms like muscle weakness, unexplained shortness of breath, or joint pain, and a positive result helps guide further evaluation, including lung imaging and pulmonary function testing, since lung involvement is often the most serious complication.
Tests that include Anti-Jo-1
This test measures Jo-1 autoantibodies. It is used to evaluate patients with suspected scleroderma, dermatomyositis, or polymyositis.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
This test measures Jo-1 autoantibodies. It is used to evaluate patients with suspected scleroderma, dermatomyositis, or polymyositis.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
ANA + 11 Components is a comprehensive blood test that includes the presence of antinuclear antibodies (ANAs), which are autoantibodies targeting the cell nucleus. A positive ANA screen suggests potential autoimmune activity. 11 ANA Components tests for 11 specific autoantibodies against distinct nuclear antigens, helping to identify or differentiate particular autoimmune diseases.
- Chromatin Antibodies Autoantibodies that target chromatin (DNA-protein complexes) inside your cells. Associated with lupus and other autoimmune conditions.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
- Ribosomal P Antibody An autoantibody associated with lupus, particularly linked to neuropsychiatric symptoms in some patients.
- RNP Antibody An autoantibody associated with mixed connective tissue disease and, at times, lupus.
- Smith (Sm) Antibody An autoantibody highly specific for lupus, though present in only a portion of people with the disease.
- Centromere B Antibody Autoantibodies that target a structure inside your cells called the centromere. Strongly associated with limited scleroderma (CREST syndrome).
- Double-Stranded DNA (dsDNA) Antibody Antibodies against double-stranded DNA. Highly specific for lupus and often used to track disease activity.
- Scleroderma (Scl-70) Antibody An autoantibody strongly associated with diffuse systemic sclerosis (scleroderma), a more widespread form of the disease.
- Sjögren's Syndrome A (SS-A/Ro) Antibody An autoantibody associated with Sjögren's syndrome and lupus; also relevant in pregnancy due to a risk of neonatal heart complications.
- Sjögren's Syndrome B (SS-B/La) Antibody An autoantibody associated with Sjögren's syndrome and lupus, often found alongside SS-A antibodies.
- Sm/RNP Antibody Measures antibodies to the Sm/RNP complex, autoantibodies linked to mixed connective tissue disease and lupus, used when evaluating a positive ANA.
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