Anti-Jo-1 details
Description
Anti-Jo-1 is an autoantibody that targets an enzyme involved in protein synthesis, and it's the most common of a group of antibodies called anti-synthetase antibodies. Its presence is strongly associated with antisynthetase syndrome, an autoimmune condition that typically involves some combination of muscle inflammation (myositis, including polymyositis and dermatomyositis), interstitial lung disease, joint inflammation, and characteristic skin changes on the hands ('mechanic's hands'). Testing for anti-Jo-1 is typically prompted by symptoms like muscle weakness, unexplained shortness of breath, or joint pain, and a positive result helps guide further evaluation, including lung imaging and pulmonary function testing, since lung involvement is often the most serious complication.
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Blood tests with Anti-Jo-1
Explore available tests to better understand your results and gain deeper insights into your health.
Single marker
Jo-1 Abs
$163.99
This test measures Jo-1 autoantibodies. It is used to evaluate patients with suspected scleroderma, dermatomyositis, or polymyositis.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
Jo-1 Antibody
$30.49
This test is primarily used to help diagnose conditions like polymyositis, dermatomyositis, and overlap syndromes such as polymyositis/scleroderma (PM/SCL) or polymyositis/systemic lupus erythematosus (PM/SLE). The presence of Jo-1 Antibody is most common in polymyositis, occurring in about 31% of cases.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
Panel
ANA + 11 Components
$1,803.99
ANA + 11 Components is a comprehensive blood test that includes the presence of antinuclear antibodies (ANAs), which are autoantibodies targeting the cell nucleus. A positive ANA screen suggests potential autoimmune activity. 11 ANA Components tests for 11 specific autoantibodies against distinct nuclear antigens, helping to identify or differentiate particular autoimmune diseases.
- Chromatin Antibodies Autoantibodies that target chromatin (DNA-protein complexes) inside your cells. Associated with lupus and other autoimmune conditions.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
- Ribosomal P Antibody An autoantibody associated with lupus, particularly linked to neuropsychiatric symptoms in some patients.
- RNP Antibody An autoantibody associated with mixed connective tissue disease and, at times, lupus.
- SS-A (Ro) Abs An autoantibody associated with Sjögren's syndrome and lupus; also relevant in pregnancy due to a risk of neonatal heart complications.
- SS-B (La) Abs An autoantibody associated with Sjögren's syndrome and lupus, often found alongside SS-A antibodies.
- Centromere b antibody
- DNA (ds) Antibody
- Scleroderma Ab
- Sm Ab
- Sm/RNP Antibody