Centromere B Antibody details
What Centromere B Antibody shows
Centromere antibodies are autoantibodies that target the centromere, a structure involved in cell division found inside the nucleus of your cells. Their presence is strongly associated with limited cutaneous systemic sclerosis, a form of scleroderma often referred to by the acronym CREST (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). A positive result, especially combined with a suggestive symptom pattern like Raynaud's phenomenon and skin changes limited to the hands, face, and lower arms/legs, supports this diagnosis and generally correlates with a milder, more limited disease course than the diffuse form of scleroderma, which is more often linked to Scl-70 antibodies instead.
Tests that include Centromere B Antibody
Centromere Antibodies (Centromere Abs) are autoantibodies that target proteins in the centromere region of chromosomes. They are most commonly associated with limited cutaneous systemic sclerosis (formerly CREST syndrome), a form of scleroderma. Testing for these antibodies helps in diagnosing autoimmune connective tissue diseases and assessing disease type and prognosis.
- Centromere B Antibody Autoantibodies that target a structure inside your cells called the centromere. Strongly associated with limited scleroderma (CREST syndrome).
Centromere Antibodies (Centromere Abs) are autoantibodies that target proteins in the centromere region of chromosomes. They are most commonly associated with limited cutaneous systemic sclerosis (formerly CREST syndrome), a form of scleroderma. Testing for these antibodies helps in diagnosing autoimmune connective tissue diseases and assessing disease type and prognosis.
- Centromere B Antibody Autoantibodies that target a structure inside your cells called the centromere. Strongly associated with limited scleroderma (CREST syndrome).
ANA + 11 Components is a comprehensive blood test that includes the presence of antinuclear antibodies (ANAs), which are autoantibodies targeting the cell nucleus. A positive ANA screen suggests potential autoimmune activity. 11 ANA Components tests for 11 specific autoantibodies against distinct nuclear antigens, helping to identify or differentiate particular autoimmune diseases.
- Chromatin Antibodies Autoantibodies that target chromatin (DNA-protein complexes) inside your cells. Associated with lupus and other autoimmune conditions.
- Anti-Jo-1 An autoantibody associated with certain autoimmune muscle and lung conditions, including polymyositis, dermatomyositis, and antisynthetase syndrome.
- Ribosomal P Antibody An autoantibody associated with lupus, particularly linked to neuropsychiatric symptoms in some patients.
- RNP Antibody An autoantibody associated with mixed connective tissue disease and, at times, lupus.
- Smith (Sm) Antibody An autoantibody highly specific for lupus, though present in only a portion of people with the disease.
- Centromere B Antibody Autoantibodies that target a structure inside your cells called the centromere. Strongly associated with limited scleroderma (CREST syndrome).
- Double-Stranded DNA (dsDNA) Antibody Antibodies against double-stranded DNA. Highly specific for lupus and often used to track disease activity.
- Scleroderma (Scl-70) Antibody An autoantibody strongly associated with diffuse systemic sclerosis (scleroderma), a more widespread form of the disease.
- Sjögren's Syndrome A (SS-A/Ro) Antibody An autoantibody associated with Sjögren's syndrome and lupus; also relevant in pregnancy due to a risk of neonatal heart complications.
- Sjögren's Syndrome B (SS-B/La) Antibody An autoantibody associated with Sjögren's syndrome and lupus, often found alongside SS-A antibodies.
- Sm/RNP Antibody Measures antibodies to the Sm/RNP complex, autoantibodies linked to mixed connective tissue disease and lupus, used when evaluating a positive ANA.
Not sure how to read your results? We can help.
Schedule a consultation with a Hormunity specialist. We’ll walk through every marker, interpret what it means for you, and map out the next steps for your care.
Book a specialist