Histamine intolerance is more than just “seasonal allergies.” It’s a chronic overload of histamine in the body — a situation where the amount you take in and release is greater than your body’s ability to break down and clear.
Histamine is a natural molecule involved in immune defense, stomach acid production, and even brain signaling. But too much histamine triggers symptoms like:
Your body uses two key enzymes to keep histamine in check:
Methylation is essential for HNMT to deactivate histamine. Variations in genes like MTHFR, MTR, and COMT can slow methylation, leading to histamine build-up. Without proper methylation support, even normal histamine levels can cause symptoms.
Gluten and dairy don’t just cause digestive distress in sensitive people — they can worsen histamine overload by:
For some, removing gluten and dairy leads to a noticeable reduction in allergy-like symptoms and improved tolerance to histamine-rich foods.
By understanding histamine metabolism, genetic influences, and dietary triggers, you can address the root causes of allergies and histamine intolerance — not just mask symptoms.
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