The liver “packages” reactive compounds from Phase I by attaching them to other molecules so they can be safely excreted.
Each conjugation route requires distinct nutrients - all equally important for safe detoxification.
GLUTATHIONE CONJUGATION
Glutathione binds toxins, making them water-soluble for bile and urine excretion.
- Support with Glutathione Complex™ - take 1 mL (≈ 2 pumps) and hold in mouth 30 seconds before swallowing, once daily
- Works synergistically with Detox Boost™ to recycle used glutathione and protect cells
AMINO ACID CONJUGATION
Uses amino acids (glycine, taurine, glutamine) and N-Acetylcysteine to neutralize acids and metabolites.
Support with Detox II Phase Support™ - take 6 caps daily between meals (3 caps twice daily); provides amino acids and sulfur donors.
Support with NAC Glutathione Support™ take 2 caps on an empty stomach, once or divided into two doses. NAC is a key sulfur donor that boosts intracellular glutathione and protects liver cells during toxin conversion.
Enhanced by Liver & Gallbladder Synergy™ for bile flow and liver cell repair.
METHYLATION
Transfers methyl groups to deactivate estrogens, histamine, and neurotransmitters.
Methylation depends on genes like MTHFR; polymorphisms can slow detox and elevate homocysteine.
When methylation is sluggish, the body struggles to clear toxins efficiently.
Most people carry some folate-cycle variation, which lowers methylation capacity.
Without support this can lead to:
– Slow detox -> High homocysteine -> Cardiovascular risk
– Oxidative stress -> Cognitive decline -> Neurological imbalance
Because these gene variations are permanent, ongoing methylation support is essential:
- Use bioactive B vitamins (methyl-B6, B12, folate) through diet or separate supplementation
- Continue Phase II support with amino acids, NAC and sulfur nutrients for conjugation balance
Supporting the liver’s detoxification phases is important for everyone, whether or not genetic polymorphisms exist.
Since testing each phase is rarely available, preventive care should emphasize activating Phase II and keeping both phases in sync.
This ensures toxins are converted, neutralized, and eliminated safely, protecting the body from oxidative stress and hormonal overload.
- Support with Detox II Phase Support™ - amino acids (glycine, taurine, sulfur donors) for Phase II conjugation
- Combine with a balanced diet and, if needed, a methylated B-complex for methylation support
- Result: better hormone balance, mood stability, cardiovascular and neurological health
SULFATION
Adds sulfur groups to detoxify hormones and food additives.
- Support with Detox II Phase Support™ (taurine, cysteine, methionine) NAC™ and Glutathione Complex™
ACETYLATION
Deactivates caffeine, smoke residues, and aromatic amines.
- Support with Mito Energy Boost™ for acetyl-CoA and Magnesium Balance™ as cofactor
GLUCURONIDATION
Binds glucuronic acid to estrogens and pollutants for bile excretion.
- Support with Liver & Gallbladder Synergy™ (bile-support herbs) and Detox Boost™ (curcumin, rosemary, green tea extract)
If Phase I outpaces Phase II, reactive toxins can accumulate.
Synchronizing phases with nutrients and antioxidants prevents detox side effects like headaches or fatigue.