HLA-DQB1 details
Description
HLA-DQB1 refers to a specific gene within the broader HLA-DQ genetic region, relevant both to celiac disease risk assessment (since the DQ2 and DQ8 patterns associated with celiac disease are defined by specific DQB1 variants) and to tissue typing for organ and stem cell transplant matching, where a close HLA match between donor and recipient reduces the risk of transplant rejection or graft-versus-host disease.
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Blood tests with HLA-DQB1
Explore available tests to better understand your results and gain deeper insights into your health.
Panel
HLA-DRB1, DQB1, Intermediate Resolution
$685.49
HLA typing is used to match donors and recipients for bone marrow and solid organ transplantation.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA-DRB1 A genetic marker used in tissue typing for transplant matching and studied in relation to autoimmune disease risk, including rheumatoid arthritis.
HLA Intermediate Resolution DR1/3/4/5, DQ
$768.99
This test identifies a patient's HLA DRB1/3/4/5 and DQB1 genotypes.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA-DRB1 A genetic marker used in tissue typing for transplant matching and studied in relation to autoimmune disease risk, including rheumatoid arthritis.
- HLA-DRB3 A genetic marker used in HLA tissue typing, relevant to transplant matching and certain autoimmune and neurological associations.
- HLA-DRB4 A genetic marker used in HLA tissue typing, relevant to transplant matching and certain autoimmune associations.
- HLA-DRB5 A genetic marker used in HLA tissue typing, relevant to transplant matching and certain autoimmune associations.
HLA Intermediate Resolution DR1/3/4/5, DQ (Allele-Resolved DRB3/4/5)
$963.49
This test identifies a patient's HLA DRB1/3/4/5 and DQB1 genotypes.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA-DRB1 A genetic marker used in tissue typing for transplant matching and studied in relation to autoimmune disease risk, including rheumatoid arthritis.
- HLA DRB3-1
- HLA DRB3-2
- HLA DRB4-1
- HLA DRB4-2
- HLA DRB5-1
- HLA DRB5-2
HLA Typing for Celiac Disease
$533.49
Celiac disease is a multigenic immune-mediated enteropathy triggered by dietary proteins, commonly known as glutens, present in wheat, barley, and rye. Varied clinical manifestations begin either in childhood or adult life. Its prevalence in the united states ranges from 0.5 to 1%. Celiac disease is strongly associated with the HLA genetic region. Approximately 90% of celiac patients express the HLA-DQ2 molecule. Most of the DQ2 negative patients express the HLA-DQ8 molecule. Gluten peptides presented by these HLA molecules induce an abnormal mucosal immune response and tissue damage. The HLA-DQ molecules are heterodimers of an alpha and a beta chain. The beta chain of HLA-DQ2 is coded by HLA-DQB102 and of DQ8 by HLA-DQB10302. HLA-DQB1 genotyping allows clinicians to evaluate the genetic predisposition for celiac disease in a patient.
- HLA-DQ2 A genetic marker strongly associated with celiac disease; most people with celiac carry this or the related HLA-DQ8 gene.
- HLA-DQ8 A genetic marker associated with celiac disease, carried by a smaller share of celiac patients than HLA-DQ2.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA DQA1*