HLA Typing for Celiac Disease
Labcorp
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HLA Typing for Celiac Disease
Quest Diagnostics
Same-day appointments in most metros.
BiomarkersQuest Diagnostics biomarkers
- HLA-DQ2 A genetic marker strongly associated with celiac disease; most people with celiac carry this or the related HLA-DQ8 gene.
- HLA-DQ8 A genetic marker associated with celiac disease, carried by a smaller share of celiac patients than HLA-DQ2.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA DQA1*
$533.49
Description
Celiac disease is a multigenic immune-mediated enteropathy triggered by dietary proteins, commonly known as glutens, present in wheat, barley, and rye. Varied clinical manifestations begin either in childhood or adult life. Its prevalence in the united states ranges from 0.5 to 1%. Celiac disease is strongly associated with the HLA genetic region. Approximately 90% of celiac patients express the HLA-DQ2 molecule. Most of the DQ2 negative patients express the HLA-DQ8 molecule. Gluten peptides presented by these HLA molecules induce an abnormal mucosal immune response and tissue damage. The HLA-DQ molecules are heterodimers of an alpha and a beta chain. The beta chain of HLA-DQ2 is coded by HLA-DQB102 and of DQ8 by HLA-DQB10302. HLA-DQB1 genotyping allows clinicians to evaluate the genetic predisposition for celiac disease in a patient.
Included biomarkers
Biomarkers
- HLA-DQ2 A genetic marker strongly associated with celiac disease; most people with celiac carry this or the related HLA-DQ8 gene.
- HLA-DQ8 A genetic marker associated with celiac disease, carried by a smaller share of celiac patients than HLA-DQ2.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA DQA1*
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
ConsultationsConsultation
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