HLA DRB4-1 details
What HLA DRB4-1 shows
HLA-DRB4 is one of the HLA class II genes, which help immune cells recognize protein fragments. Not everyone has a DRB4 gene on each copy of chromosome 6; it is present only alongside certain HLA-DRB1 types. Because you inherit one set of HLA genes from each parent, typing reports up to two results, and DRB4-1 is the first of them. Intermediate-resolution HLA typing is mainly used for matching in organ or stem cell transplantation and sometimes in disease-association work. The result is a lifelong genetic type, not a level, and it has no "high" or "low" meaning. It is interpreted together with the rest of the HLA typing.
Tests that include HLA DRB4-1
A person's HLA type and antibody profile are important for assessing immunological compatibility between donor and recipient, as incompatibility can result in transplant rejection. HLA typing and antibody testing can help assess donor-recipient immunological risk.
- HLA DRB3-1 The first of two reported HLA-DRB3 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB3-2 The second of two reported HLA-DRB3 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB4-1 The first of two reported HLA-DRB4 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB4-2 The second of two reported HLA-DRB4 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB5-1 The first of two reported HLA-DRB5 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB5-2 The second of two reported HLA-DRB5 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
This test identifies a patient's HLA DRB1/3/4/5 and DQB1 genotypes.
- HLA-DQB1 A genetic marker used in celiac disease risk assessment and in tissue-typing for organ/stem cell transplant matching.
- HLA-DRB1 A genetic marker used in tissue typing for transplant matching and studied in relation to autoimmune disease risk, including rheumatoid arthritis.
- HLA DRB3-1 The first of two reported HLA-DRB3 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB3-2 The second of two reported HLA-DRB3 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB4-1 The first of two reported HLA-DRB4 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB4-2 The second of two reported HLA-DRB4 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB5-1 The first of two reported HLA-DRB5 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
- HLA DRB5-2 The second of two reported HLA-DRB5 allele results from HLA typing, describing an inherited immune gene used in transplant matching and some disease-association studies.
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