Protein C Antigen details
What Protein C Antigen shows
This test measures the actual amount of Protein C protein present in your blood, as distinct from the activity test, which measures how well that Protein C is functioning. Comparing antigen (amount) and activity results helps characterize the type of Protein C deficiency present — a 'type I' deficiency shows both low amount and low activity, while a 'type II' deficiency shows a normal amount of Protein C that isn't working properly, a distinction that can matter for genetic counseling and family screening.
Tests that include Protein C Antigen
This profile helps to confirm and characterize protein C deficiency.
- Protein C Antigen Measures the actual amount of Protein C protein present, used together with the activity test to fully characterize a Protein C deficiency.
This profile helps to confirm and characterize protein C deficiency.
- Protein C Antigen Measures the actual amount of Protein C protein present, used together with the activity test to fully characterize a Protein C deficiency.
Aids in characterization of protein C deficiency. Type I deficiency is characterized by reduction in activity (functional) and antigen levels. With type II deficiency (dysfunctional protein), antigen levels may be normal and activity levels are decreased. Acquired deficiencies may occur with vitamin K antagonists/deficiency, liver disease, malignancy, consumptive DIC, surgery, trauma, and hepatic immaturity of the newborn. Drug therapy with L-asparaginase or fluorouracil can also reduce Protein C antigen levels.
- Protein C Activity Measures the activity of Protein C, a natural anticoagulant. Low activity is linked to an increased risk of blood clots.
- Protein C Antigen Measures the actual amount of Protein C protein present, used together with the activity test to fully characterize a Protein C deficiency.
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