Immunoglobulin G Subclass 2 details
What Immunoglobulin G Subclass 2 shows
Immunoglobulin G (IgG) is the main antibody type in your blood and is divided into four subclasses. IgG2 is the second most abundant and is particularly important for responding to polysaccharides, the sugar coatings on bacteria such as pneumococcus and Haemophilus influenzae. It is measured to help evaluate your immune function, especially with recurrent sinus, ear, or lung infections. A low IgG2 level can point to a subclass deficiency, sometimes even when total IgG looks normal. A high level is less common and is usually non-specific. Because some people with low levels have no problems, results are interpreted alongside vaccine responses, especially to pneumococcal vaccine, and your infection history.
Tests that include Immunoglobulin G Subclass 2
Measurement of IgG subclasses may be helpful in the management and understanding of immunodeficiency diseases, hypersensitivity states, and conditions involving susceptibility to infection.
- Immunoglobulin G (IgG) Your most abundant antibody class, providing long-term immune memory against past infections. Low levels can point to an immune deficiency.
- Immunoglobulin G Subclass 1 Measures IgG1, the most abundant of the four IgG antibody subclasses, to help evaluate immune function in people with frequent or unusual infections.
- Immunoglobulin G Subclass 2 Measures IgG2, the IgG antibody subclass important for fighting bacteria with sugar coatings, to help evaluate immune function in people with recurrent infections.
- Immunoglobulin G Subclass 3 Measures IgG3, an IgG antibody subclass that is especially active against viruses and in activating the immune system, to help evaluate recurrent infections.
- Immunoglobulin G Subclass 4 A subclass of IgG antibodies. Elevated levels are associated with IgG4-related disease, a rare inflammatory condition that can affect multiple organs.
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