Kappa/Lambda Light Chains, Free with Ratio Blood Test
Compare labs
| Feature |
Labcorp
|
Quest Diagnostics
|
|---|---|---|
| Price | Coming soon | $57.99 |
| Results in | — | ~5 business days |
| Sample type | — | Blood Serum |
| Require fasting | — | No |
About the test
The Kappa/Lambda Light Chains, Free with Ratio, Serum test measures the amount of kappa and lambda free light chains (FLCs) in the blood and calculates the kappa to lambda ratio. It is used to assist in the diagnosis of plasma cell disorders, including multiple myeloma, primary amyloidosis, monoclonal gammopathy of unknown significance (MGUS), Waldenström’s macroglobulinemia, and related disorders. It is also used to monitor disease activity and treatment [1].
Kappa and lambda light chains link with heavy chains to form immunoglobulins. In healthy individuals, most serum light chains are bound to heavy chains. However, excess plasma-cell proliferation associated with plasma-cell disorders can cause an excess of circulating FLCs and increase or decrease the K/L ratio [1].
This test is intended for patients clinically suspected of having hematologic disease, based on certain symptoms and medical conditions. These include bone pain, bone fractures, normocytic anemia, kidney disease, and recurrent infections suggestive of an underlying plasma-cell disorder [1].
Note that blood samples that are grossly hemolyzed or lipemic or contain high levels of circulating immune complexes (CICs) should not be tested, because of the unpredictable degree of nonspecific scatter these sample types may generate.
References
- AACC. Serum free light chains. https://labtestsonline.org/tests/serum-free-light-chains. Accessed September 3, 2019.
Included biomarkers & Reference ranges
| Biomarker | Reference range |
|---|---|
| Kappa/Lambda Light Chains Free With Ratio A calculated ratio of free kappa to free lambda light chains in serum, used to help detect and monitor plasma cell disorders such as multiple myeloma. | — |
| Kappa Light Chain, Free Measures free kappa light chains in serum, small antibody pieces made by plasma cells, used with lambda light chains to help evaluate plasma cell disorders. | — |
| Lambda Light Chain, Free Measures free lambda light chains in serum, small antibody pieces made by plasma cells, used with kappa light chains to help evaluate plasma cell disorders. | — |
Reference ranges vary by lab, age, and sex (M/F). Your report shows your exact range. Click any biomarker to see its optimal range and what your results mean.
How it works
- 1. Order online No referral or insurance
- 2. Get a requisition By email, instantly
- 3. Visit a draw center Bring a matching photo ID
- 4. Get results Securely by email
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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