Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) details
What Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) shows
The PLAC® test measures Lp-PLA2, an enzyme linked to inflammation specifically within artery walls, produced by certain white blood cells involved in plaque formation. Unlike more general inflammatory markers like CRP, Lp-PLA2 is thought to reflect inflammation more specific to the blood vessels themselves, and it's used as an additional marker to help refine cardiovascular risk assessment, particularly in people whose risk based on standard factors alone is unclear or borderline.
Tests that include Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
This test measures the activity of Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme linked to inflammation and found in atherosclerotic plaques. High levels of Lp-PLA2 are associated with an increased risk of coronary heart disease and stroke. This test can help identify individuals at higher risk of cardiovascular events, aiding in the decision to start or intensify risk reduction strategies.
- Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Measures an enzyme linked to inflammation within artery walls, used as an additional marker to help assess cardiovascular risk.
The PLAC test for Lp-PLA2 activity is an enzyme assay that quantitatively measures Lp-PLA2 activity in blood samples. It can help predict the risk of coronary heart disease in patients with no prior history of cardiovascular events.
- Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Measures an enzyme linked to inflammation within artery walls, used as an additional marker to help assess cardiovascular risk.
Advanced Lipid Panel with Inflammation, Cardio IQ This test goes beyond the standard lipid panel to provide a more comprehensive assessment of cardiovascular disease (CVD) risk. According to the 2013 ACC/AHA guidelines, it's important to match statin treatment intensity with the absolute risk of cardiovascular events. This test includes advanced CVD markers like ion mobility, ApoB, lp(a), hsCRP, and Lp-PLA2, offering a clearer picture of your CVD risk.
- Apolipoprotein B The main protein found on LDL and other 'bad' cholesterol particles. Considered a strong indicator of cardiovascular risk, since each particle carries one ApoB molecule.
- Low-Density Lipoprotein (LDL) Cholesterol The 'bad' cholesterol that can build up in artery walls. A core marker used to assess cardiovascular disease risk.
- LDL Size Measures the average size of your LDL ('bad' cholesterol) particles; smaller, denser particles are considered more likely to contribute to artery plaque.
- Lipoprotein(a) A genetically-determined, LDL-like particle. Elevated levels are an independent, largely inherited risk factor for cardiovascular disease.
- Total Cholesterol The combined measure of all cholesterol in your blood — HDL, LDL, and other lipoproteins together. A foundational marker of cardiovascular risk.
- Triglycerides A type of fat in your blood used for energy storage. Elevated levels are linked to increased cardiovascular risk and often reflect diet, weight, or metabolic health.
- HDL Cholesterol The 'good' cholesterol that helps remove excess cholesterol from your bloodstream. Higher levels are generally linked to lower cardiovascular risk.
- HDL Large The concentration of large HDL particles in your blood, measured as part of an advanced lipid panel to add detail on cardiovascular risk.
- C-Reactive Protein, High Sensitivity (hs-CRP) A sensitive marker of low-grade inflammation in the body, commonly used to help assess cardiovascular disease risk.
- LDL Medium Measures medium-sized LDL particles by ion mobility, part of an advanced lipid profile that looks at the size and number of LDL particles.
- LDL Particle Number LDL particle number — counts your actual LDL ('bad' cholesterol) particles rather than just the cholesterol they carry, often a stronger cardiovascular risk indicator than standard LDL cholesterol.
- LDL Pattern A classification of your LDL particle size profile as pattern A (mostly large particles) or pattern B (mostly small, dense particles), from ion mobility testing.
- LDL Small Measures small, dense LDL particles, a lipid subfraction associated with higher cardiovascular risk and insulin resistance.
- Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Measures an enzyme linked to inflammation within artery walls, used as an additional marker to help assess cardiovascular risk.
- Non-HDL Cholesterol Total cholesterol minus HDL — capturing all the potentially artery-clogging ('bad') cholesterol particles in one number.
- Total Cholesterol / HDL Ratio Compares your total cholesterol to your HDL ('good') cholesterol, offering a quick snapshot of cardiovascular risk balance.
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