Hydroxyitraconazole details
What Hydroxyitraconazole shows
Hydroxyitraconazole is formed when your liver breaks down itraconazole, an antifungal medicine used for infections such as aspergillosis and other fungal diseases. Unlike many breakdown products, it is active against fungi itself, so it contributes to the medicine's overall effect. It is measured in serum together with itraconazole as part of therapeutic drug monitoring, because absorption of itraconazole varies a lot from person to person. Low combined levels can mean the medicine is not being absorbed well or doses are being missed, while high levels can raise the chance of side effects. Timing of the blood draw relative to the last dose matters, so results are read by the prescriber.
Tests that include Hydroxyitraconazole
The antifungal drug itraconazole is active in the treatment of aspergillosis, blastomycosis, histoplasmosis, sporotrichosis, and onychomycosis. It is a protein-bound drug and thus has negligible CSF penetration. It may also be utilized in the treatment of systemic candidiasis and cryptococcosis, especially when other drugs are contraindicated or ineffective. The chronic nature of fungal infections demands constant monitoring of itraconazole levels within a patient to ensure that adequate therapeutic levels of the drug are administered, absorbed and subsequently excreted
- Hydroxyitraconazole The main active breakdown product of the antifungal medicine itraconazole, measured in serum to help check that drug levels are in an effective range.
- Itraconazole Measures the level of the antifungal medicine itraconazole in serum, used to check that you are absorbing enough of it for treatment to work.
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