Fc Epsilon Receptor (RI + RII) Antibody details
What Fc Epsilon Receptor (RI + RII) Antibody shows
Mast cells and basophils carry the high-affinity IgE receptor, Fc epsilon RI, while the low-affinity receptor, Fc epsilon RII (CD23), is found mainly on other immune cells such as B cells. In some people with chronic urticaria (long-lasting hives), the immune system makes autoantibodies against Fc epsilon RI or against IgE itself, which can activate these cells and cause histamine release without any allergen being involved. This marker is reported as part of a histamine release assay, which tests whether something in your serum triggers basophils to release histamine. A positive result suggests an autoimmune contribution to chronic hives. A negative result does not rule one out, and the result is interpreted alongside your symptoms, history and other tests.
Tests that include Fc Epsilon Receptor (RI + RII) Antibody
Chronic Urticaria (CU) is a common skin disorder affecting 1 to 6% of the general population. It is characterized by repeated occurrence of short-lived cutaneous wheals accompanied by redness and itching. Autoimmune urticaria is defined by the presence of a functional IgG antibody to high-affinity IgE receptor (Fc epsilon RI alpha) or IgE. These antibodies trigger mast cell and basophil degranulation by the engagement of Fc epsilon receptor. Functional IgG antibody to the receptor has been identified in approximately 30-40% of patients with CU, and anti IgE antibody has been identified in another 5%-10%.
- Fc Epsilon Receptor (RI + RII) Antibody Looks for autoantibodies against IgE receptors on immune cells, which can trigger histamine release and help explain some cases of chronic hives.
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