Chromatin (Nucleosomal) Antibody details
What Chromatin (Nucleosomal) Antibody shows
Chromatin is the combination of DNA and the proteins it is wrapped around, and its basic unit is called the nucleosome. This test measures autoantibodies against chromatin, meaning antibodies your immune system has made against parts of your own cell nuclei. It is mainly used in the assessment of systemic lupus erythematosus (lupus), and it is also associated with drug-induced lupus. A positive result is associated with lupus and related autoimmune conditions, and higher levels may be seen with more active disease, including kidney involvement. These antibodies can occasionally appear in other conditions, so the result does not diagnose lupus on its own and is interpreted with ANA, anti-dsDNA and your symptoms.
Tests that include Chromatin (Nucleosomal) Antibody
This test is crucial for understanding the autoimmune response in systemic lupus erythematosus (SLE), a condition where the body's immune system mistakenly attacks its own tissues. About 90% of people with SLE show positive results for this test, indicating their immune system is reacting to nucleosomes, which are components of the cell's nucleus.
- Chromatin (Nucleosomal) Antibody Measures antibodies against chromatin (nucleosomes), the DNA-protein units in cell nuclei, used to help assess lupus and drug-induced lupus.
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