Quest AD-Detect Apolipoprotein E (ApoE) Isoform, Plasma Blood Test
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| Feature |
Labcorp
|
Quest Diagnostics
|
|---|---|---|
| Price | Coming soon | $320.49 |
| Results in | — | ~5 business days |
| Sample type | — | Blood Plasma |
| Require fasting | — | No |
About the test
Apolipoprotein E (ApoE) is a well-defined genetic risk factor for late-onset Alzheimer's disease (AD). The human APOE gene has three polymorphic alleles, E2, E3 and E4 that result in six different genotypes: E2/E2, E2/E3, E3/E3, E2/ E4, E3/E4 and E4/E4. About half of AD patients carry the E4 allele (compared with 14% in the general population), with the majority being heterozygotes (E3/E4). The number of inherited E4 alleles is associated with both increased disease risk and decreased average age of onset compared with inheritance of the E2 or E3 alleles. The differences between the three ApoE isoforms are based on two amino acids that affect its structure and hence the interaction and binding of the protein with various lipids and beta-amyloid (AB). ApoE and AB can co-localize in the brain, and therefore their complementary roles in AD have been studied extensively. Circulating plasma and CSF ApoE levels were recently found to be potential biomarkers for AD.
Included biomarkers & Reference ranges
| Biomarker | Reference range |
|---|---|
| APOE Phenotype Identifies which apolipoprotein E forms (E2, E3, E4) are in your blood, which reflect inherited gene variants linked to Alzheimer's and heart disease risk. | — |
Reference ranges vary by lab, age, and sex (M/F). Your report shows your exact range. Click any biomarker to see its optimal range and what your results mean.
How it works
- 1. Order online No referral or insurance
- 2. Get a requisition By email, instantly
- 3. Visit a draw center Bring a matching photo ID
- 4. Get results Securely by email
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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