HDL Cholesterol Subclasses Blood Test
Compare labs
| Feature |
Labcorp
|
Quest Diagnostics
|
|---|---|---|
| Price | Coming soon | $56.49 |
| Results in | — | ~5 business days |
| Sample type | — | Blood Serum |
| Require fasting | — | No |
About the test
This test measures the concentrations of 2 major high-density lipoprotein (HDL) cholesterol subclasses (HDL2 cholesterol and HDL3 cholesterol) and may be used in studying the correlation between HDL subclasses and certain diseases, especially coronary heart disease (CHD) risk.
HDL is a heterogeneous group of particles that transports lipids, such as cholesterol and triglycerides. Based on hydrated densities, HDL can be divided into HDL2 (40% of total HDL) and HDL3 (60% of total HDL); HDL3 is smaller and denser. HDL2 and HDL3 differ in composition, functionality, and atherogenic or atheroprotective properties [1].
HDL cholesterol level has been inversely related to the CHD risk, but simply increasing total HDL cholesterol levels could not reduce future cardiovascular events [1]. Therefore, the atheroprotective properties of HDL were assumed to be rooted in the functionality of different HDL particles instead of total HDL cholesterol concentration. The value of HDL subgroup measurements for assessing CHD risk and various other conditions have been investigated, but whether HDL2 or HDL3 is the beneficial subfraction for CHD remains unclear [1].
The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.
Reference
- Lappegard KT, et al. Biomedicines. 2021;9(7):836.
Included biomarkers & Reference ranges
| Biomarker | Reference range |
|---|---|
| HDL-2 Cholesterol Measures cholesterol carried in HDL-2, the larger, more buoyant subclass of HDL particles, to give more detail than a standard HDL result. | — |
| HDL-3 Cholesterol Measures cholesterol carried in HDL-3, the smaller, denser subclass of HDL particles, to give more detail than a standard HDL result. | — |
Reference ranges vary by lab, age, and sex (M/F). Your report shows your exact range. Click any biomarker to see its optimal range and what your results mean.
Preparation
- If a cholesterol measurement is to be performed along with other lipid tests, the patient should fast 9-12 hours prior to collection.
How it works
- 1. Order online No referral or insurance
- 2. Get a requisition By email in 24–72 hours
- 3. Visit a draw center Bring a matching photo ID
- 4. Get results Securely by email
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Not sure how to read your results? We can help.
Schedule a consultation with a Hormunity specialist. We’ll walk through every marker, interpret what it means for you, and map out the next steps for your care.
Book a specialist