Cortisol, LC/MS, Saliva, 2 Samples Test
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| Feature |
Labcorp
|
Quest Diagnostics
|
|---|---|---|
| Price | Coming soon | $116.99 |
| Results in | — | ~5 business days |
| Sample type | — | Saliva |
| Require fasting | — | No |
About the test
Salivary cortisol level, particularly late-night salivary cortisol (LNSC) level, is useful in screening for endogenous Cushing syndrome. Two or more positive results of LNSC tests may be used to confirm Cushing syndrome. LNSC measurement may also be used to monitor for recurrence of Cushing disease [1].
Normally, the secretion of cortisol has a circadian rhythm. Patients with Cushing syndrome often lose the late-night circadian nadir. Therefore, an elevated LNSC level may provide initial evidence for Cushing syndrome. Two or more positive results of LNSC tests may establish the diagnosis of Cushing syndrome if non-neoplastic hypercortisolism (pseudo-Cushing syndrome) is excluded. Because saliva is convenient to collect, LNSC testing is especially useful for individuals who need to provide multiple specimens over time for the evaluation of cyclic Cushing syndrome [1].
Annual LNSC testing is recommended to monitor for the recurrence of Cushing disease after pituitary surgery. LNSC testing may also be used in assessing treatment outcomes in patients receiving medical therapy for Cushing disease [1].
Non-neoplastic hypercortisolism caused by obesity, psychiatric disorders, alcohol use disorder, and polycystic ovary syndrome may increase LNSC levels. LNSC testing should not be used to screen for Cushing syndrome in individuals without normal day and night cycles. LNSC testing has low sensitivity in patients with adrenal tumors [1].
Other tests, such as urinary free cortisol (test code 14534) and dexamethasone suppression test (test code 6921), may also be used to screen for Cushing syndrome. Choice of tests should be individualized based upon clinical scenarios [1].
The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.
Reference
- Fleseriu M, et al. Lancet Diabetes Endocrinol. 2021;9(12):847-875.
Included biomarkers & Reference ranges
| Biomarker | Reference range |
|---|---|
| Cortisol, 1st Specimen Measures cortisol in the first of a series of timed samples, used to track how your cortisol changes across the day or during a test. | — |
| Cortisol, 2nd Specimen Measures cortisol in the second of a series of timed samples, used to track how your cortisol changes across the day or during a test. | — |
Reference ranges vary by lab, age, and sex (M/F). Your report shows your exact range. Click any biomarker to see its optimal range and what your results mean.
Preparation
- Collect your saliva sample at least 60 minutes after brushing teeth, eating a meal (liquid/solid food intake), or oral intake of medication.
- Collect your saliva sample 10 minutes after rinsing your mouth with water in order to avoid contamination of the saliva by interfering substances.
How it works
- 1. Order online No referral or insurance
- 2. Get a requisition By email in 24–72 hours
- 3. Visit a draw center Bring a matching photo ID
- 4. Get results Securely by email
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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