Phosphorylated Tau 217 (p-tau217) details
What Phosphorylated Tau 217 (p-tau217) shows
Phosphorylated tau 217 (pTau217) is a form of tau, a protein in nerve cells, that rises in the blood when amyloid plaques and tau tangles, the brain changes of Alzheimer's disease, are present. This plasma test is used in adults with memory or thinking symptoms to help assess how likely those Alzheimer's changes are. A higher result suggests Alzheimer's-type changes are more likely, while a lower result makes them less likely. It does not diagnose Alzheimer's disease on its own, and kidney function and other factors can affect levels, so results are interpreted by a clinician alongside cognitive assessment and, where needed, further testing.
Tests that include Phosphorylated Tau 217 (p-tau217)
Current research indicates that plasma p-tau, including p-tau 217, is concordant with amyloid status defined by either CSF biomarker testing or PET scan analysis, and is able to differentiate between AD and non-AD neurodegenerative diseases and to predict progression to AD. Blood-based biomarkers, such as plasma p-tau, could potentially be used as inclusion criteria or to evaluate target engagement and treatment efficacy, and could further advance the development of disease-modifying treatments in the field of AD and related disorders. This assay is designed specifically for the quantitative measurement of tau phosphorylated at threonine 217 (p-tau 217) in human plasma.
- Phosphorylated Tau 217 (p-tau217) Measures phosphorylated tau 217 in plasma, a blood marker linked to the brain changes of Alzheimer's disease, used in people with memory symptoms.
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