Parietal Cell Antibodies details
What Parietal Cell Antibodies shows
Parietal cells line the stomach and make acid and intrinsic factor, a protein needed to absorb vitamin B12. In autoimmune gastritis, the immune system attacks these cells, and parietal cell antibodies are often found in the blood. This test measures them to help look into causes of low vitamin B12 or pernicious anemia. A positive result supports autoimmune gastritis, but these antibodies can also be found in people without symptoms, especially older adults and those with other autoimmune conditions such as thyroid disease. A negative result does not exclude it. The result is interpreted alongside intrinsic factor antibodies, vitamin B12 and other tests.
Tests that include Parietal Cell Antibodies
Gastric Parietal Cell Antibodies are found in 90% of patients with pernicious anemia. They are also found in autoimmune chronic atrophic gastritis preceding pernicious anemia. The antigenic target is the H+/K+ ATPase gastric proton pump responsible for parietal cell acid generation in the stomach.
- Parietal Cell Antibodies Measures antibodies against stomach parietal cells, a marker of autoimmune gastritis and a supporting test when looking into pernicious anemia.
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