Macrohepatic Isoenzymes details
What Macrohepatic Isoenzymes shows
Alkaline phosphatase (ALP) is an enzyme made in several tissues, mainly the liver and bone. An ALP isoenzyme test separates total ALP into its different forms, and macrohepatic ALP is a large, high-molecular-weight form that comes from the liver, thought to be released bound to fragments of cell membranes. It is measured when total ALP is raised, to help work out the source. Finding macrohepatic ALP generally points to the liver and bile ducts, and it is most often associated with conditions that slow or block bile flow, such as bile duct obstruction or liver involvement by other diseases. It is interpreted alongside total ALP, GGT, other liver tests, and imaging.
Tests that include Macrohepatic Isoenzymes
When the Total Alkaline Phosphatase activity is increased, the Isoenzymes are useful in determining the source of the increased activity.
- Alkaline Phosphatase (ALP) An enzyme found mainly in the liver and bones. High levels can signal liver disease, bile duct blockage, or bone conditions.
- Bone Isoenzymes Measures the bone form of alkaline phosphatase, helping show whether a raised alkaline phosphatase level comes from bone rather than the liver.
- Intestinal Isoenzymes The intestinal fraction of alkaline phosphatase, measured in serum to help work out whether a raised alkaline phosphatase comes from the intestine rather than liver or bone.
- Liver Isoenzymes The liver fraction of alkaline phosphatase, measured in serum to help work out whether a raised alkaline phosphatase comes from the liver or bile ducts.
- Macrohepatic Isoenzymes A high-molecular-weight form of liver alkaline phosphatase, measured in serum and usually linked to slowed or blocked bile flow.
- Placental Isoenzymes Measures the placental form of alkaline phosphatase, which normally rises in pregnancy and is reported as part of an alkaline phosphatase isoenzyme test.
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