Immunofixation details
What Immunofixation shows
Immunofixation is a laboratory technique that separates the proteins in your serum and then uses specific antibodies to identify which immunoglobulin heavy chain (IgG, IgA, or IgM) and light chain (kappa or lambda) make up any abnormal band. It is used to confirm and type a monoclonal protein, also called an M-protein, which is made by a single group of plasma cells. A positive result shows that a monoclonal protein is present, which can occur in monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, and related disorders. Immunofixation identifies the protein type but does not measure how much there is, so it is interpreted alongside serum protein electrophoresis and free light chains.
Tests that include Immunofixation
Monoclonal increases in IgG or IgA are often associated with diseases such as multiple myeloma, lymphomas or leukemia. A monoclonal increase in IgM is commonly associated with Waldenström's macroglobulinemia.
- Immunofixation A serum test that identifies the type of an abnormal monoclonal antibody protein, used to help evaluate conditions such as MGUS and multiple myeloma.
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