HLA-B27 Antigen details
What HLA-B27 Antigen shows
HLA-B27 is an inherited version of an HLA gene, part of the system your immune cells use to recognize proteins. This test checks whether you carry it. It is used when symptoms suggest a spondyloarthritis, such as inflammatory back pain that improves with movement, or conditions like reactive arthritis and anterior uveitis, because HLA-B27 is strongly associated with these. A positive result increases the likelihood of these conditions, but most people who carry HLA-B27 never develop them, and some people with them are negative. It is a lifelong result, not a level that changes, and it is interpreted alongside your symptoms, examination, and imaging.
Tests that include HLA-B27 Antigen
HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter's disease. Ankylosing spondylitis affects 1 in 1000 caucasians. Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen.
- HLA-B27 Antigen Checks whether you carry HLA-B27, an inherited immune gene type linked to ankylosing spondylitis and related inflammatory conditions of the spine, joints, and eyes.
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