Histone Antibodies details
What Histone Antibodies shows
Histones are proteins that DNA wraps around inside the nucleus of your cells. This test measures autoantibodies against histones in your blood. It is mainly used when lupus-like symptoms, such as joint pain, rash, or fatigue, develop while taking certain medicines, because histone antibodies are commonly found in drug-induced lupus. A positive result can support drug-induced lupus, but these antibodies also appear in systemic lupus erythematosus and some other autoimmune conditions, so it is not specific. It is interpreted alongside an ANA test, other autoantibodies, your medication history, and your symptoms.
Tests that include Histone Antibodies
Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.
- Histone Antibodies Measures antibodies against histones, proteins that package DNA, mainly used to help evaluate drug-induced lupus and other lupus-like autoimmune conditions.
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