Chromatin IgG Antibody details
What Chromatin IgG Antibody shows
Chromatin is the combination of DNA and the proteins it is wrapped around, and its basic unit is called the nucleosome. This test measures IgG autoantibodies against chromatin, meaning antibodies your immune system has made against parts of your own cell nuclei. It is mainly used in the assessment of systemic lupus erythematosus (lupus), and it is also associated with drug-induced lupus. A positive result is associated with lupus and related autoimmune conditions, and higher levels may be seen with more active disease, including kidney involvement. These antibodies can occasionally appear in other conditions, so the result does not diagnose lupus on its own and is interpreted with ANA, anti-dsDNA and your symptoms.
Tests that include Chromatin IgG Antibody
Anti-chromatin antibodies are autoantibodies directed against the chromatin complex (a combination of DNA, RNA, and proteins within the cell nucleus). More than 50% of patients with SLE (systemic lupus erythematosus) exhibit reactivity with chromatin.
- Chromatin IgG Antibody Measures IgG antibodies against chromatin, the DNA-protein complex in cell nuclei, used to help assess lupus and drug-induced lupus.
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