Factor II (Prothrombin) DNA Analysis details

This is a genetic (DNA) test that looks for a specific mutation in the prothrombin (Factor II) gene, one of the most common inherited risk factors for developing abnormal blood clots (venous thromboembolism), after Factor V Leiden. Unlike the Factor II activity test, which measures how the protein is functioning in your blood right now, this test looks directly at your DNA to see whether you carry the mutation, which doesn't change over your lifetime. It's typically ordered as part of a thrombophilia (clotting disorder) workup after an unexplained blood clot, especially with a family history of clotting problems.