Anti-Cardiolipin IgG details

Anti-cardiolipin IgG antibodies are autoantibodies that mistakenly target cardiolipin, a phospholipid involved in normal blood clotting regulation. This IgG subtype is generally considered the most clinically significant of the three anti-cardiolipin antibody classes (IgA, IgG, IgM) for diagnosing antiphospholipid syndrome, an autoimmune condition linked to an increased risk of blood clots, recurrent miscarriage, and other pregnancy complications, particularly when present at moderate-to-high levels. It's typically tested alongside IgM anti-cardiolipin, anti-beta-2 glycoprotein antibodies, and lupus anticoagulant to build a full antiphospholipid antibody profile. A single positive result is usually confirmed with repeat testing at least 12 weeks later, since transient positives can occur with infections or certain medications.